The Big Game series, now in its sixth year, is the festive period's hottest sporting ticket and is a fantastic and affordable day out for all the family.
Starting from just £10, tickets are also priced at £15, £25 and £45, with concessions available in all categories bar the top tier (£45).
Harlequins Members have until Friday 29th November to claim their seat, which is included in the 2013/14 Membership package.
An 82,000 sell-out crowd attended the previous two Big Games and with sales already ahead of last year, the club is expecting another sell out at rugby's HQ this December.
Commenting on the Big Game 6, Matt Hopper said : "I have been fortunate enough to be involved in the last couple of years and it is a great family day out with great entertainment. It's awesome for the family to get together and have a great time around Christmas; hopefully the rugby is a good spectacle as well.
"Playing at Twickenham is amazing, the noise and the atmosphere on the day is something special. Hopefully it will be a great day."
To purchase Big Game 6 tickets, please click here, or call Harlequins direct on 0208 410 6010. General release tickets will not affect the Members' allocation.